Vasovagal syncope as a cause of syncope in long-QT syndrome.
نویسندگان
چکیده
Asians. It may suggest that PPR would be 1 of numerous risk factors of atherothrombosis and that the role of it may not explain the whole clinical events after percutaneous coronary intervention. Previous studies reported that high PPR is associated with poor clinical outcomes in patients with coronary artery disease (3,4). owever, it is not clear that tailored dosing or choice of antiplateet agents based on platelet function test can improve the prognosis f patients with high PPR. The GRAVITAS (Gauging Responiveness With A VerifyNow Assay–Impact on Thrombosis and afety) trial could not show the benefit of high-dose clopidogrel herapy in patients with high PPR (5). The TRIGGER-PCI Testing Platelet Reactivity in Patients Undergoing Elective Stent lacement on Clopidogrel to Guide Alternative Therapy With rasugrel) study was stopped early after an interim analysis evealed a primary event rate too low to allow for any meaningful omparison between clopidogrel and prasugrel (6). The results of major trials make us question whether PPR would be a odifiable factor of thrombosis or simply an intrinsic property eflecting one’s thrombotic status. Further studies are warranted to nvestigate these unsolved problems, especially regarding the ethic difference of response to antiplatelet regimen and the necessiies of personalized antiplatelet therapies.
منابع مشابه
Editorial Genetics of the Faint - Hearted Great Results , Alternate Hypothesis
In this issue of Circulation: Cardiovascular Genetics, Barsheshet et al shed novel and unexpected light on the genetics of syncope, defined as a transient loss of consciousness caused by cerebral hypoperfusion with spontaneous recovery. Syncope is very common, with a cumulative incidence of 37% by age 60 years.1,2 In “young” patients, by far the most common cause of syncope is vasovagal syncope...
متن کاملGenetics of the faint-hearted: great results, alternate hypothesis.
In this issue of Circulation: Cardiovascular Genetics, Barsheshet et al shed novel and unexpected light on the genetics of syncope, defined as a transient loss of consciousness caused by cerebral hypoperfusion with spontaneous recovery. Syncope is very common, with a cumulative incidence of 37% by age 60 years.1,2 In “young” patients, by far the most common cause of syncope is vasovagal syncope...
متن کاملVasovagal Syncope Treated as Epilepsy for 16 Years
The differentiation of vasovagal syncope and epileptic seizure is sometimes problematic, since vasovagal syncope may mimic epileptic seizures in many ways. The present report describes a patient who had been diagnosed and treated as having epilepsy with medically-refractory sei-zures for 16 years. Often, unlike epileptic seizures, tonic-clonic convulsions and postictal confusion are uncommon fe...
متن کاملهای اسید گلوتامیک، تریپتوفان، آلانین tRNA بررسی مولکولی در Long QT وآسپارژین درژنوم میتوکندری بیماران مبتلا بهسندرم مقایسه با گروه کنترل
Background and purpose: Long QT syndrome is a heart arrhythmia identified by prolongation of the QT interval which is a cause of sudden cardiac death in young individuals. In most cases, abnormalities in heart repolarization are reasons of prolongation of action potential and arrhythmia. The activity of ion channels is sensitive to ATP level, therefore, mitochondrial disorders are considered...
متن کاملEvaluation of syncope.
Syncope is a transient and abrupt loss of consciousness with complete return to preexisting neurologic function. It is classified as neurally mediated (i.e., carotid sinus hypersensitivity, situational, or vasovagal), cardiac, orthostatic, or neurogenic. Older adults are more likely to have orthostatic, carotid sinus hypersensitivity, or cardiac syncope, whereas younger adults are more likely t...
متن کاملPrediction of Vasovagal Syncope based on Body Vigilance and Alexithymia Variables
Introduction: Vasovagal syncope is the most common type of syncope and recurrent syncope attacks can have a profound effect on the patients' quality of life. The aim of this study was to predict vasovagal syncope based on the variables of body vigilance and alexithymia. Methods: The present study was a case-control study. The statistical population of the present study included the patients wi...
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ورودعنوان ژورنال:
- Journal of the American College of Cardiology
دوره 58 2 شماره
صفحات -
تاریخ انتشار 2011